collecte section Bourgogne

https://www.helloasso.com/associations/association-france-lyme/collectes/section-bourgogne

More evidence for the ways borrelia can change their gene expression in this paper:


More evidence for the ways borrelia can change their gene expression in this paper:
"The telomere resolvase of the Lyme disease spirochete, Borrelia burgdorferi, promotes DNA single-strand annealing and strand exchange"
by Taskia Mir, Shu Hui Huang and Kerri Kobryn
"One of the most intriguing examples of recombination at hairpin telomeres is the gene conversion that drives antigenic variation of the vlsE expression site locus. The
single expression site for VlsE is located immediately upstream of a linear plasmid telomere. Information in the variable region of the vlsE gene is replaced by information from an array of silent copies of the vls variable region located upstream of the telomeric expression site;
the silent vls cassette array is arranged in inverted repeat orientation with respect to the expression site. vls switching usually involves short conversions of the variable portion of the vlsE expression site from unexpressed donor site(s) in a process that is RecA-independent but dependent on the branch migration motor RuvAB, implying the involvement of some variety of RecA-independent strand exchange reaction"
 
 
 from Denise 
I only understand this in a general way - which is that Borrelia have the ability to pick up foreign DNA using the end segments of the chromosome almost like a lasso.