collecte section Bourgogne

https://www.helloasso.com/associations/association-france-lyme/collectes/section-bourgogne

REPORTS ALLEN STEERE, 27 YEARS AGO: "In both syphilis and Lyme disease, serodiagnostic tests often give false-negative results early in the illness (

REPORTS ALLEN STEERE, 27 YEARS AGO: "In both syphilis and Lyme disease, serodiagnostic tests often give false-negative results early in the illness (12, 36, 37). However, in syphilis, use of a flagellar-associated protein to which an early IgM response is directed (37), rather than a crude sonicate of spirochetes on the solid phase of an ELISA, improved the-sensitivity of the test (36). This observation suggests that the 41 -kD antigen of B. burgdorferi may give better results in an ELISA for early Lyme disease than the current test, which uses sonicated whole spirochetes (1 1, 12). Furthermore, in this study, IgM antibodies to the 41-kD polypeptide were usually apparent by immunoblots before IgM titers were elevated by the current ELISA (12). Although antibodies reactive against this antigen may be present in patients with relapsing fever or syphilis (11,14), these diseases can be distinguished clinically from Lyme disease and therefore should not cause diagnostic confusion. The binding of this antigen by IgM from rheumatic disease controls was typically very weak and could potentially be blocked to avoid false-positive results in this group of patients." Per, Kathleen Dickson Respectively.
ncbi.nlm.nih.gov