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Relationship of Inflammation and Autoimmunity to Psychiatric Sequelae in Lyme Disease


Relationship of Inflammation and Autoimmunity to Psychiatric Sequelae in Lyme Disease

Robert C. Bransfield, MD, DLFAPA

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Psychiatric Annals
September 2012 - Volume 42 · Issue 9: 337-341
DOI: 10.3928/00485713-20120906-07

Abstract

CME Educational Objectives
1. Gain a better understanding of the pathophysiology of Lyme disease and other tick-borne diseases.

2. Learn to understand how a sequence of immune-mediated events in Lyme disease and other tick-borne disease can result in psychiatric symptoms.


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3. Recognize that infection and immune reactions in the body can affect the brain.


The causative spirochete of Lyme disease, Borrelia burgdorferi, is the most common human tick-borne pathogen in the Northern hemisphere. It is also probably the most complex bacteria known, as it has 132 genes and 21 plasmids, with 90% of this genetic material unrelated to any known bacteria.


LYD/TBD is associated with multisystemic symptoms, including psychiatric symptoms. Currently, there are 240 peer-reviewed articles demonstrating the association between LYD/TBD and psychiatric symptoms.

The most common mental symptoms include fatigue; nonrestorative sleep; impairments of executive functioning, attention, memory, and processing speed; sensory hyperacusis; and low frustration tolerance, irritability, depression, and anxiety.

Psychiatric symptoms are more significant with Babesia and Bartonella coinfections. A combination of our current limitations in understanding this disease, misinformation regarding this disease, and the failure to diagnose and treat it in the early stages results in a significant burden of psychiatric illness associated with LYD/TBD.

AUTHORS

Robert C. Bransfield, MD, DLFAPA, is a Clinical Associate Professor, Robert Wood Johnson UMDNJ Medical School.

Address correspondence to: Robert C. Bransfield, MD, DLFAPA, 225 Highway 35, Red Bank, NJ 07701; fax: 732-741-5308; email: Bransfield@comcast.net.

Disclosure: Dr. Bransfield has no relevant financial relationships to disclose.

doi: 10.3928/00485713-20120906-07
‎- Brandaktuell aus den USA - CME Article

Relationship of Inflammation and Autoimmunity to Psychiatric Sequelae in Lyme Disease

Robert C. Bransfield, MD, DLFA...